Contact Information

Harry Scheinin
CEO and co-owner
Auvaisbergin rantatie 93
FIN-20760 Piispanristi
Finland

Phone +358 400 825 599

info [at] omnicon.fi

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List of Publications - Harry Scheinin

Original articles in international peer-reviewed scientific journals

Laaksonen L,  Kallioinen M, Långsjö J, Laitio T, Scheinin A, Scheinin J, Kaisti K, Maksimow A, Kallionpää RE, Rajala V, Johansson J, Kantonen O, Nyman M, Sirén S, Valli K, Revonsuo A, Solin O, Vahlberg T, Alkire M, Scheinin H. Comparative effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study. Br J Anaest 2018;121:281-290.

Kallionpää RE, Scheinin A, Kallionpää RA, Sandman N, Kallioinen M, Laitio R, Laitio T, Kaskinoro K, Kuusela T, Revonsuo A, Scheinin H, Vall K. Spoken words are processed during dexmedetomidine-induced unresponsiveness. Br J Anaesth 2018;121:270-280.

Radek L, Kallionpää RE, Karvonen M, Scheinin A, Maksimow, Långsjö, Kaisti K, Vahlberg T, Revonsuo A, Scheinin H, Valli K. Dreaming and awareness during dexmedetomidine- and propofol-induced unresponsiveness. Br J Anaest 2018;121:260-269.

Scheinin A, Kallionpää RE, Li D, Kallioinen M, Kaisti K, Långsjö J, Maksimow A, Vahlberg T, Valli K, Mashour GA, Revonsuo A, Scheinin H. Differentiating drug-related and state-related effects of dexmedetomidine and propofol on the electroencephalogram. Anesthesiology 2018;129:22-36.

Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T; Xe-HYPOTHECA Study Group. Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. J Am Coll Cardiol 2017;70:2652-2660.

Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T. Effect of inhaled xenon on cerebral white matter damage in comatose survivors of out-of-hospital cardiac arrest: A randomized clinical trial. JAMA 2016; 315:1120-1128.

Lehto J, Scheinin A, Johansson J, Marjamäki P, Arponen E, Scheinin H, Scheinin M. Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [11C]ORM-13070. Synapse 2016;70:57-65.

Lehto J, Johansson J, Vuorilehto L, Luoto P, Arponen E, Scheinin H, Rouru J, Scheinin M. Sensitivity of [11C]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects. Psychopharmacology (Berl) 2015; 232:4169-78.

Virtanen S, Utriainen KT, Parkkola R, Airaksinen JK, Laitio R, Scheinin H, Hakovirta H, Laitio TT; BAROSLEEP Study Group. White matter damage of the brain is associated with poor outcome in vascular surgery patients with claudication: a pilot study. Eur J Vasc Endovasc Surg 2014;48:687-693.

Lehto J, Hirvonen MM, Johansson J, Kemppainen J, Luoto P, Naukkarinen T, Oikonen V, Arponen E, Rouru J, Sallinen J, Scheinin H, Vuorilehto L, Finnema SJ, Halldin C, Rinne JO, Scheinin M. Validation of [11C]ORM-13070  as a PET tracer for alpha2C-adrenoceptors in the human brain. Synapse 2015;69:172-181.

Aalto S, Ingman K, Alakurtti K, Kaasinen V, Virkkala J, Någren K, Rinne JO, Scheinin H. Intravenous ethanol increases dopamine release in the ventral striatum in humans:  PET study using bolus-plus-infusion administration of [11C]raclopride. J Cereb Blood Flow Metab 2015;35:424-431.

Maksimow A,  Silfverhuth M, Långsjö J, Kaskinoro K, Georgiadis S, Jääskeläinen S, Scheinin H. Directional connectivity between frontal and posterior brain regions is altered with increasing concentrations of propofol. PLoS ONE 2014 Nov 24;9(11):e113616. doi: 10.1371/journal.pone.0113616. eCollection 2014.

Kaskinoro K, Maksimow A, Georgiadis S, Långsjö J, Scheinin H, Karjalainen P, Jääskeläinen SK. Electroencephalogram reactivity to verbal command after dexmedetomidine, propofol and sevoflurane-induced unresponsiveness. Anaesthesia 2015;70:190-204.

Utriainen KT, Airaksinen JK, Polo O, Laitio R, Pietilä MJ, Scheinin H, Vahlberg T, Leino KA, Kentala ES, Jalonen JR, Hakovirta H, Parkkola R, Virtanen S, Laitio TT. Sleep apnoea is associated with major cardiac events in peripheral arterial disease. Eur Respir J 2014;43:1652-1660.

Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT. Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Crit Care Med 2013;41:2116-2124.

Utriainen KT, Airaksinen JK, Polo O, Raitakari OT, Pietilä MJ, Scheinin H, Helenius HY, Leino KA, Kentala ES, Jalonen JR, Hakovirta H, Salo TM, Laitio TT. Unrecognised obstructive sleep apnoea is common in severe peripheral arterial disease. Eur Resp J 2013;41:616-620.

Hagelberg N, Aalto S, Tuominen L, Pesonen U, Någren K, Hietala J, Scheinin H, Pertovaara A, Martikainen IK. Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects. Neurosci Lett 2012;521:11-14.

Långsjö JW, Alkire MT, Kaskinoro K, Hayama H, Maksimow A, Kaisti KK, Aalto S, Aantaa R, Jääskeläinen SK, Revonsuo A, Scheinin H. Returning from oblivion: imaging the neural core of consciousness; J Neurosci 2012;32:4935-4943.

Tarvainen MP, Georgiadis S, Laitio T, Lipponen JA, Karjalainen PA, Kaskinoro K, Scheinin H. Heart rate variability dynamics during low-dose propofol and dexmedetomidine anesthesia. Ann Biomed Eng 2012 Mar 15 [Epub ahead of print].

Noreika V, Jylhänkangas L, Móró L, Valli K, Kaskinoro K, Aantaa R, Scheinin H, Revonsuo A. Consciousness lost and found: Subjective experiences in an unresponsive state. Brain Cogn 2011;77:327-334.

Kaskinoro K, Maksimow A, Långsjö J, Aantaa R, Jääskeläinen S, Kaisti K, Särkelä M, Scheinin H. Wide inter-individual variability of bispectral index and spectral entropy at loss of consciousness during increasing concentrations of dexmedetomidine, propofol, and sevoflurane. Br J Anaesth 2011;107:573-580.

Leino K, Hynynen M, Jalonen J, Salmenperä M, Scheinin H, Aantaa R for the Dexmedetomidine in Cardiac Surgery Study Group. Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study. BMC Anesthesiology 2011;11:9

Mäenpää M, Laitio T, Kuusela T, Penttilä J, Kaisti K, Aalto S, Hinkka-Yli-Salomäki S, Scheinin H. Delta entropy of heart rate variability along with deepening anesthesia. Anest Analg 2011;112:587-592.

Kaskinoro K, Maksimow A, Scheinin H, Laitio R, Aantaa R, Kärki T, Jääskeläinen S, Hinkka-Yli-Salomäki S. Normobaric hyperoxia does not induce significant electroencephalogram changes in healthy male subjects. Internet J Neuromonit 2010:6 (1).

Hirvonen MM, Lumme V, Hirvonen J, Pesonen U, Någren K, Vahlberg T, Scheinin H, Hietala J. C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. Prog Neurophsychopharmacol Biol Psychiatry 2009;33:630-636.

Laitio RM, Långsjö JW, Aalto S, Kaisti KK, Salmi E, Maksimow A, Aantaa R, Oikonen V, Viljanen T, Parkkola R, Scheinin H. The effects of xenon anesthesia on the relationship between cerebral glucose metabolism and blood flow in healthy subjects – A positron emission tomography study. Anesth Analg 2009;108:593-600.

Aalto S, Hirvonen J, Kaasinen V, Hagelberg N, Kajander J, Någren K, Seppälä T, Rinne JO, Scheinin H, Hietala J. The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: A randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects. Eur J Nucl Med Mol Imaging 2009;36:475-483.

Hirvonen J, Aalto S, Hagelberg N, Maksimow A, Ingman K, Oikonen V, Virkkala J, Någren K, Scheinin H. Measurement of central µ-opioid receptor binding in vivo with PET and [11C]carfentanil: A test-retest study in healthy subjects. Eur J Nucl Med Mol Imaging 2009;36:275-286.

Salmi E, Aalto S, Hirvonen J, Långsjö JW, Maksimow AT, Oikonen V, Metsähonkala L, Virkkala J, Någren K, Scheinin H. Measurement of GABA-A receptor binding in vivo with [11C]flumazenil: A test-retest study in healthy subjects. NeuroImage 2008;41:260-269.

Salmi E, Laitio RM, Aalto S, Maksimow AT, Långsjö JW, Kaisti KK, Aantaa R, Oikonen V, Metsähonkala L, Någren K, Korpi ER, Scheinin H. Xenon does not affect gamma-aminobutyric acid type A receptor binding in humans, Anesth Analg 2008;106:129-134.

Laitio RM, Kaskinoro K, Särkelä MO, Kaisti KK, Salmi E, Maksimow A, Långsjö JW, Aantaa R, Kangas K, Jääskeläinen S, Scheinin H. Bispectral index, entropy and quantitative electroencephalogram during single-agent xenon anesthesia. Anesthesiology 2008;108:63-70.

Huupponen E, Maksimow A, Lapinlampi P, Särkelä M, Saastamoinen A, Snapir A, Scheinin H, Scheinin M, Meriläinen P, Himanen SL, Jääskeläinen S. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 2008;52:289-294.

Silvanto M, Munsterhjelm E, Savolainen S, Tiainen P, Niemi T, Ylikorkala O, Scheinin H, Olkkola KT. Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia. Acta Anaesthesiol Scand 2007;51:1147-1154.

Laitio RM, Kaisti KK, Långsjö JW, Aalto S, Salmi E, Maksimow A, Aantaa, R, Oikonen V, Sipilä H, Parkkola R, Scheinin H. Effects of xenon anesthesia on cerebral blood flow in humans – a positron emission tomography study. Anesthesiology 2007;106:1128-1133.

Mäenpää M, Penttilä J, Laitio T, Kaisti K, Kuusela T, Hinkka S, Scheinin. The effects of surgical levels of sevoflurane and propofol anaesthesia on heart rate variability. Eur J Anaesth 2007;24:626-633.

Maksimow A, Snapir A, Särkelä M, Kentala E, Koskenvuo J, Posti J, Jääskeläinen SK, Hinkka-Yli-Salomäki S, Scheinin M, Scheinin H. Assessing the depth of dexmedetomidine-induced sedation with electroencephalogram (EEG)-based spectral entropy. Acta Anaesthesiol Scand 2007;51:22-30.

Snapir A, Posti J, Kentala E, Koskenvuo J, Sundell J, Tuunanen H, Hakala K, Scheinin H, Knuuti J, Scheinin M. Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects. Anesthesiology 2006;105:902-910.

Maksimow A, Särkela M, Långsjö JW, Salmi E, Kaisti KK, Yli-Hankala A, Hinkka-Yli-Salomäki S, Scheinin H, Jääskeläinen SK. Increase in high frequency EEG activity explains the poor performance of EEG spectral entropy monitor during S-ketamine anesthesia. Clin Neurophysiol 2006;117:1660-1668.

Penttilä J, Snapir A, Kentala E, Koskenvuo J, Posti J, Scheinin M, Scheinin, Kuusela T. Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods. Eur J Clin Pharmacol 2006;62:401-407.

Laitio TT, Huikuri HV, Koskenvuo J, Jalonen J, Mäkikallio TH, Helenius H, Kentala ES, Hartiala J, Scheinin H. Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery. Anesth Analg 2006;102:1026-1031.

Penttilä J, Mäenpää M, Laitio T, Långsjö J, Hinkka S, Scheinin H. Sub-anaesthetic doses of ketamine impair cardiac parasympathetic regulation. Eur J Anaesth 2005;22:808-810.

Salmi E, Långsjö JW, Aalto S, Någren K, Metsähonkala L, Kaisti KK, Korpi ER, Hietala J, Scheinin H: Subanesthetic ketamine does not affect 11C-flumazenil binding in humans. Anesth Analg 2005;101:722-725.

Maksimow A, Kaisti K, Aalto S, Maenpaa M, Jaaskelainen S, Hinkka S, Martens S, Sarkela M, Viertio-Oja H, Scheinin H. Correlation of EEG spectral entropy with regional cerebral blood flow during sevoflurane and propofol anaesthesia. Anaesthesia 2005;60:862-869.

Långsjö JW, Maksimow A, Syrjänen E. Kaisti KK, Aalto S, Oikonen V, Hinkka S, Aantaa R, Sipilä H, Viljanen T, Parkkola R, Scheinin H. S-ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans. Anesthesiology 2005;103:258-268.

Aalto S, Ihalainen J, Hirvonen J, Kajander J, Scheinin H, Tanila H, Någren K, Vilkman H, Gustafsson LL, Syvälahti E, Hietala J. Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man. Psychopharmacology 2005;182:375-383.

Ingman K, Hagelberg N, Aalto S, Någren K, Juhakoski A, Karhuvaara S, Kallio A, Oikonen V, Hietala J, Scheinin H. Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing. Neuropsychopharmacol 2005;30:2245-2253.

Lund VE, Kentala E, Scheinin H, Lertola K, Klossner J, Aitasalo K, Sariola-Heinonen K, Jalonen J. Effect of age and repeated hyperbaric oxygen treatments on vagal tone. Undersea Hyperb Med. 2005; 32:111-119.

Martikainen IK, Hagelberg N, Mansikka H, Hietala J, Någren K, Scheinin H, Pertovaara A. Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia. Neurosci Lett 2005;376:149-153.

Penttilä J, Kaila T, Helminen A, Anttila M, Karhuvaara S, Huhtala S, Scheinin H. Effects of atipamezole – a selective a2-adrenoceptor antagonist – on cardiac parasympathetic regulation in human subjects. Auton Autacoid Pharmacol 2004;24:69-75.

Salmi E, Kaisti KK, Metsähonkala L, Oikonen V, Aalto S, Någren K, Hinkka S, Hietala J, Korpi ER, Scheinin H. Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans. Anesth Analg 2004;99:1420-1426.

Antila S, Pesonen U, Lehtonen L, Tapanainen P, Nikkanen H, Vaahtera K, Scheinin H. Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators. Eur J Pharma Sci 2004;23:213-222.

Pertovaara A, Martikainen IK, Hagelberg N, Mansikka H, Någren K, Hietala J, Scheinin H. Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain. Eur J Neurosci 2004;20:1587-1592.

Penttilä J, Helminen A, Anttila M, Hinkka S, Scheinin H. Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects. Can J Physiol Pharm 2004;82:359-362.

Kaisti KK, Mäkitalo J, Sipilä HT, Teräs MI, Scheinin H. Ventilator add-on for delivering PET tracer gases. J Nucl Med Technol 2004;32:79-82.

Laitio T, Huikuri H, Mäkikallio T, Jalonen J, Kentala E, Helenius H, Pullisaar O, Hartiala J, Scheinin H. The breakdown of fractal heart rate dynamics predicts prolonged postoperative myocardial ischemia. Anesth Analg 2004;98:1239-1244.

Långsjö JW, Salmi E, Kaisti KK, Aalto S, Hinkka S, Aantaa R, Oikonen V, Viljanen T, Kurki T, Silvanto M, Scheinin H. Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans. Anesthesiology 2004;100:1065-1071.

Hagelberg N, Aalto S, Kajander J, Oikonen V, Hinkka S, Någren K, Hietala J, Scheinin H. Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects. Pain 2004;109:86-93.

Laine K, De Bruyn S, Björklund H, Rouru J, Hänninen J, Scheinin H, Anttila M. Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics. Eur J Clin Pharmacol. 2004;59:893-898.

Penttilä J, Helminen A, Jartti T, Kuusela T, Huikuri HV, Tulppo MP, Scheinin H. Effect of cardiac vagal outflow on complexity and fractal correlation properties of heart rate dynamics. Auton Autacoid Pharmacol 2003;23:173-179.

Anttila M, Penttilä J, Helminen A, Vuorilehto L, Scheinin H. Bioavailability of dexmedetomidine after extravascular doses in healthy subjects. Br J Clin Pharmacol 2003;56:691-693.

Jääskeläinen SK, Kaisti K, Suni L, Hinkka S, Scheinin H. Sevoflurane is epileptogenic in healthy subjects at surgical levels of anesthesia. Neurology 2003;61:1073-1078.

Hagelberg N, Forssell H, Aalto S, Rinne JO, Scheinin H, Taiminen T, Någren K, Eskola O, Jääskeläinen SK. Altered dopamine D2 receptor binding in atypical facial pain. Pain 2003;106:43-48.

Långsjö JW, Kaisti KK, Aalto S, Hinkka S, Aantaa R, Oikonen V, Sipilä H, Kurki T, Silvanto M, Scheinin H. Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003;99:614-623.

Kaisti KK, Långsjö JW, Aalto S, Oikonen V, Sipilä H, Teräs M, Hinkka S, Metsähonkala L, Scheinin H. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003;99:603-613.

Lund V, Laine J, Laitio T, Kentala E, Jalonen J, Scheinin H. Instantaneous beat-to-beat variability reflects vagal tone during hyperbaric hyperoxia. Undersea Hyperb Med. 2003;30:29-36.

Hagelberg N, Forssell H, Rinne JO, Scheinin H, Taiminen T, Aalto S, Luutonen S, Någren K, Jääskeläinen S. Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain 2003;101:149-154.

Aalto S, Hirvonen J, Kajander J, Scheinin H, Någren K, Vilkman H, Gustafsson L, Syvälahti E, Hietala J. Ketamine does not decrease striatal dopamine D2 receptor binding in man. Psychopharmacology 2002;164:401-406.

Hagelberg N, Martikainen IK, Mansikka H, Hinkka S, Någren K, Hietala J, Scheinin H, Pertovaara A. Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity. Pain 2002;99:273-279.

Kaisti KK, Metsähonkala L, Teräs M, Oikonen V, Aalto S, Jääskelainen S, Hinkka S, Scheinin H. Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology 2002;96:1358-1370.

Hagelberg N, Kajander JK, Någren K, Hinkka S, Hietala J, Scheinin H. Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man. Synapse 2002;45:25-30.

Laitio TT, Mäkikallio TH, Huikuri HV, Kentala ES, Uotila P, Jalonen JR, Helenius H, Hartiala J, Yli-Mäyry S, Scheinin H. Relation of heart rate dynamics to the occurrence of myocardial ischemia after coronary artery bypass grafting. Am J Cardiol 2002;89:1176-1181.

Persson J, Hasselstrom J, Maurset A, Oye I, Svensson JO, Almqvist O, Scheinin H, Gustafsson LL, Almqvist O. Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity. Eur J Clin Pharmacol 2002;57:869-875.

Ahokoski O, Irjala K, Taalikka M, Manninen P, Halonen K, Kangas L, Salminen E, Huupponen R, Scheinin H. Pharmacokinetics of finrozole (MPV-2213ad), a novel selective aromatase inhibitor, in healthy men. Brit J Clin Pharmaco 2001;52:702-704.

Mildh LH, Scheinin H, Kirvelä OA. The concentration-effect relationship of the respiratory depressant effects of alfentanil and fentanyl. Anesth Analg 2001;93:939-946.

Penttilä J, Helminen A, Jartti T, Kuusela T, Huikuri HV, Tulppo MP, Coffeng R, Scheinin H. Time domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patterns. Clin Physiol 2001;21:365-376.

Penttilä J, Helminen A, Luomala K, Scheinin H. Pharmacokinetic-pharmacodynamic model for the anticholinergic effect of glycopyrrolate. Eur J Clin Pharmacol 2001;57:153-158.

Penttilä J, Vesalainen R, Helminen A, Kuusela T, Hinkka S, Rahi K, Kaila T, Scheinin H. Spontaneous baroreflex sensitivity as a dynamic measure of cardiac anticholinergic drug effect. J Auton Pharm 2001;21:71-78.

Penttilä J, Syvälahti E, Hinkka S, Kuusela T, Scheinin H. The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomized placebo-controlled study on healthy volunteers. Psychopharmacology 2001;154:343-349.

Lund V, Kentala E, Scheinin H, Klossner J, Sariola-Heinonen K, Jalonen J. Hyperbaric oxygen increases parasympathetic activity in professional divers. Acta Physiol Scand 2000;170:39-44.

Scheinin H, Virtanen T, Kentala E, Uotila P, Laitio T, Hartiala J, Heikkilä H, Sariola-Heinonen K, Pullisaar O, Yli-Mäyry S, Jalonen J. Epidural infusion of bupivacaine and fentanyl reduces perioperative myocardial ischaemia in elderly patients with hip fracture - a randomized controlled trial. Acta Anaesthesiol Scand 2000;44:1061-1070.

Laitio TT, Huikuri HV, Kentala ESH, Mäkikallio TH, Jalonen JR, Helenius H, Sariola-Heinonen K, Yli-Mäyry S, Scheinin H. Correlation properties and complexity of perioperative RR-interval dynamics in coronary artery bypass surgery patients. Anesthesiology 2000;93:69-80.

Luukkaa V, Rouru J, Ahokoski O, Scheinin H, Irjala K, Huupponen R. Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men. Eur J Endocrinol 2000;142:164-169.

Kaisti KK, Jääskeläinen SK, Rinne JO, Metsähonkala E-L, Scheinin H. Epileptiform discharges during 2 MAC sevoflurane anesthesia in two healthy volunteers. Anesthesiology 1999;91:1952-1955.

Ahokoski O, Virtanen A, Kairisto V, Scheinin H, Huupponen R, Irjala K. Biological day-to-day variation and reference change limits of serum cortisol and aldosterone in healthy young men on unrestricted diets. Clin Chem 1999;45:1097-1099.

Lund VE, Kentala E, Scheinin H, Klossner J, Helenius H, Sariola-Heinonen K, Jalonen J. Heart rate variability in healthy volunteers during normobaric and hyperbaric hyperoxia. Acta Physiol Scand 1999;167:29-35.

Lund V, Kentala E, Scheinin H, Klossner J, Koskinen P, Jalonen J. Effect of hyperbaric conditions on plasma stress hormone levels and endothelin-1. Undersea Hyperbar M 1999;26:87-92.

Persson J, Scheinin H, Hellström G, Björkman S, Götharsson E, Gustafsson LL. Ketamine antagonizes alfentanil-induced hypoventilation in healthy male volunteers. Acta Anaesthesiol Scand 1999;43:744-752.

Ahokoski O, Irjala K, Huhtala S, Salminen E, Scheinin H, Huupponen R. A double-blind study of MPV-2213ad, a novel aromatase inhibitor, in healthy male subjects. Eur J Clin Pharmacol 1999;55:27-34.

Scheinin H, Helminen A, Grönroos P, Huhtala S, Bosch J, Kuusela T, Kanto J, Kaila T. Spectral analysis of heart rate variability as a quantitative measure of parasympatholytic effect - integrated pharmacokinetics and pharmacodynamics of three anticholinergic drugs. Ther Drug Monit 1999;21:141-151.

Sundberg S, Antila S, Scheinin H, Häyhä M, Virtanen M, Lehtonen L. Integrated pharmacokinetics and pharmacodynamics of the novel calcium sensitizer levosimendan as assessed by systolic time intervals. Int J Clin Pharmacol Ther 1998;36:629-635.

Wakelkamp M, Alvįn G, Scheinin H, Gabrielsson J. The influence of drug input rate on the development of tolerance to frusemide. Brit J Clin Pharmaco 1998;46:479-487.

Scheinin H, Anttila M, Dahl M-L, Karnani H, Nyman L, Taavitsainen P, Pelkonen O, Bertilsson L. CYP2D6 polymorphism is not crucial for the disposition of selegiline. Clin Pharmacol Ther 1998;64:402-411.

Scheinin H, Aantaa R, Anttila M, Hakola P, Helminen A, Karhuvaara S. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific a2-adrenoceptor antagonist atipamezole - a pharmacodynamic and kinetic study in healthy volunteers. Anesthesiology 1998;89:574-584.

Tallila T, Polo O, Aantaa R, Lepistö M, Lahdenperä A, Scheinin H. Nocturnal body movements and hypoxemia in middle-aged females after lower abdominal surgery under general anesthesia. A study with the Static-Charge-Sensitive-Bed (SCSB). J Clin Monitor Comp 1998;14:239-244.

Ahokoski O, Virtanen A, Huupponen R, Scheinin H, Salminen E, Kairisto V, Irjala K. Biological day-to-day variation and daytime changes of testosterone, follitropin, lutropin and oestradiol-17 in healthy men. Clin Chem Lab Med 1998;36:485-491.

Kirvelä O, Jaatinen J, Scheinin H, Kanto J. The effects of branced chain amino acid infusion on pain perception, respiration, and plasma concentrations of monoamines. Pharmacol Biochem Behav 1998;60:77-82.

Ahokoski O, Irjala K, Huupponen R, Halonen K, Salminen E, Scheinin H. Hormonal effects of MPV-2213ad, a new selective aromatase inhibitor, in healthy male subjects. A phase I study. Brit J Clin Pharmaco 1998;45:141-146.

Kentala E, Scheinin H, Kaila T, Seppälä T, Kanto J. Pharmacokinetics and clinical effects of intramuscular scopolamine plus morphine. Acta Anaesthesiol Scand 1998;42:323-328.

Sipilä J, Scheinin H, Grenman R. Laser bronchoscopy in palliative treatment of malignant obstructing endobronchial tumors. ORL J Otorhinolaryngol Relat Spec 1998;60:42-47.

Grönroos PE, Irjala KM, Huupponen RK, Scheinin H, Forsström J, Forsström JJ. A medication database - a tool for detecting drug interactions in hospital. Eur J Clin Pharmacol 1997;53:13-17.

Irjala J, Koskinen P, Scheinin M, Kanto J, Scheinin H. Biochemical and clinical assessment of histamine blockade. Int J Clin Pharmacol Ther 1996;34:269-273.

Wilson AJ, Diemunsch P, Lindeque BG, Scheinin H, Helbo-Hansen HS, Kroeks MVAM, Kong KL. Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting. Brit J Anaesth 1996;76:515-518.

Huupponen R, Karhuvaara S, Anttila M, Vuorilehto L, Scheinin H. Buccal delivery of an a2-adrenergic receptor antagonist, atipamezole, in humans. Clin Pharmacol Ther 1995;58:506-511.

Levänen J, Mäkelä M-L, Scheinin H. Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. Anesthesiology 1995;82:1117-1125.

Scheinin H, Havia T, Pekkala E, Huovinen P, Klossner J, Lehto H, Niinikoski J. Aspoxicillin versus piperacillin in severe abdominal infections - a comparative phase III study. J Antimicrob Chemoth 1994;34:813-817.

Virkkilä M, Ali-Melkkilä T, Scheinin H, Turunen J, Kanto J. Dexmedetomidine as intramuscular premedication in day-case cataract surgery. A comparative study of dexmedetomidine, midazolam and placebo. Anaesthesia 1994;49:853-858.

Jaakola M-L, Kanto J, Scheinin H, Kallio A. Intramuscular dexmedetomidine premedication - an alternative to midazolam-fentanyl-combination in elective hysterectomy. Acta Anaesthesiol Scand 1994;38:238-243.

Aho M, Erkola O, Kallio A, Scheinin H, Korttila K. Comparison of dexmedetomidine and midazolam and antagonism of dexmedetomidine with atipamezole. J Clin Anest 1993;5:194-203.

Scheinin H, Jaakola M-L, Sjövall S, Ali-Melkkilä T, Kaukinen S, Turunen J, Kanto J. Intramuscular dexmedetomidine as premedication for general anesthesia - a comparative multicenter study. Anesthesiology 1993;78:1065-1075.

Koulu M, Pesonen U, Koskinen S, Scheinin H, Virtanen R, Scheinin M. Reduced turnover of dopamine and 5-hydroxytryptamine in discrete dopaminergic, noradrenergic and serotonergic rat brain areas after acutely administered medetomidine, a selective a2-adrenoceptor agonist. Pharmacol Toxicol 1993;72:182-187.

Virkkilä M, Ali-Melkkilä T, Kanto J, Turunen J, Scheinin H. Dexmedetomidine as intramuscular premedication in outpatient cataract surgery. A placebo-controlled dose-ranging study. Anaesthesia 1993;48:482-487.

Scheinin H, Karhuvaara S, Olkkola K, Kallio A, Anttila M, Vuorilehto L, Scheinin M. Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine. Clin Pharmacol Ther 1992;52:537-546.

Aho M, Erkola O, Kallio A, Scheinin H, Korttila K. Dexmedetomidine infusion for maintenance of anesthesia in patients undergoing abdominal hysterectomy. Anesth Analg 1992;75:940-946.

Jaakola M-L, Ali-Melkkilä T, Kanto J, Kallio A, Scheinin H, Scheinin M. Dexmedetomidine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery. Brit J Anaesth 1992;68:570-575.

Scheinin B M-A, Lindgren L, Randell T, Scheinin H, Scheinin M. Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl. Brit J Anaesth 1992;68:126-131.

MacDonald E, Scheinin M, Scheinin H, Virtanen R. Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective a2-adrenoceptor agonist. J Pharmacol Exp Ther 1991;259:848-854.

Aho MS, Erkola OA, Scheinin H, Lehtinen A-M, Korttila KT. Effect of intravenously administered dexmedetomidine on pain after laparoscopic tubal ligation. Anesth Analg 1991;73:112-118.

Mattila MJ, Mattila ME, Olkkola KT, Scheinin H. Effects of dexmedetomidine and midazolam on human performance and mood. Eur J Clin Pharmacol 1991;41:217-223.

Jaakola M-L, Salonen M, Lehtinen R, Scheinin H. The analgesic action of dexmedetomidine - a novel a2-adrenoceptor agonist - in healthy volunteers. Pain 1991;46:281-285.

Scheinin M, Scheinin H, Ekblad U, Kanto J. Biological correlates of mental stress related to anticipated caesarean section. Acta Anaesthesiol Scand 1990;34:640-644.

Karhuvaara S, Kallio A, Scheinin M, Anttila M, Salonen JS, Scheinin H. Pharmacological effects and pharmacokinetics of atipamezole, a novel a2-adrenoceptor antagonist - a randomized, double blind cross-over study in healthy male volunteers. Brit J Clin Pharmaco 1990;30:97-106.

Aantaa R, Kanto J, Scheinin M, Kallio A, Scheinin H. Dexmedetomidine, an a2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynecologic surgery. Anesthesiology 1990;73:230-235.

Aantaa R, Kanto J, Scheinin M, Kallio A, Scheinin H. Dexmedetomidine premedication for minor gynecologic surgery. Anesth Analg 1990;70:407-413.

Karhuvaara S, Kallio A, Koulu M, Scheinin H, Scheinin M. No involvement of alpha2-adrenoceptors in the regulation of basal prolactin secretion in healthy men. Neuropsychopharmacol 1990;15:125-129.

Kallio A, Saraste M, Scheinin M, Hartiala J, Scheinin H. Acute hemodynamic effects of medetomidine and clonidine in healthy volunteers - a noninvasive echocardiographic study. J Cardiovasc Pharmacol 1990;16:28-33.

Kallio A, Salonen M, Forsell H, Scheinin H, Scheinin M, Tuominen J. Medetomidine premedication in dental surgery - a double-blind cross-over study with a novel a2-adrenoceptor agonist. Acta Anaesthesiol Scand 1990;34:171-175.

Karhuvaara S, Kallio A, Scheinin M, Koulu M, Scheinin H, Viikari J. Tolerability and effects of atipamezole, a novel alpha2-adrenoceptor antagonist, in healthy male volunteers. Curr Ther Res 1989;45:633-642.

Kallio A, Scheinin M, Koulu M, Ponkilainen R, Ruskoaho H, Viinamäki O, Scheinin H. Effects of dexmedetomidine, a selective alpha2-adrenoceptor agonist, on hemodynamic control mechanisms. Clin Pharmacol Ther 1989;46:33-42.

Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M. Acute effects of medetomidine, a selective alpha2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol 1988;119:11-15.

MacDonald E, Scheinin H, Scheinin M. Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. Eur J Pharmacol 1988;158:119-127.

Scheinin H, MacDonald E, Scheinin M. Behavioural and neurochemical effects of atipamezole, a novel alpha2-adrenoceptor antagonist. Eur J Pharmacol 1988;151:35-42.

Manner T, Kanto J, Scheinin H, Viinamäki O, Scheinin M. Meptazinol and pentazocine: effects on prolactin, growth hormone and vasopressin levels in plasma. Pharmacol Toxicol 1987;61:301-304.

Manner T, Kanto J, Scheinin H, Scheinin M. Meptazinol and pentazocine: plasma catecholamines and other effects in healthy volunteers. Brit J Clin Pharmaco 1987;24:689-697.

Scheinin M, Kallio A, Koulu M, Viikari J, Scheinin H. Sedative and cardiovascular effects of medetomidine, a novel selective alpha2-adrenoceptor agonist, in healthy volunteers. Brit J Clin Pharmaco 1987;24:443-451.

Scheinin H, Scheinin M. Monoamine metabolite levels in rat CSF: Kinetic studies. Pharmacol Toxicol 1987;61:167-171.

Scheinin M, Kallio A, Koulu M, Arstila M, Viikari J, Scheinin H. Dose-finding and tolerability study of medetomidine in four healthy volunteers - an open phase I investigation. Curr Ther Res 1987;41:637-646.

Scheinin M, Lindberg R, Syvälahti E, Hietala J, Pihlajamäki K, Scheinin H. Noradrenergic and dopaminergic effects of nomifensine in healthy volunteers. Clin Pharmacol Ther 1987;41:88-96

Scheinin H. Enhanced noradrenergic neuronal activity increases homovanillic acid levels in cerebrospinal fluid. J Neurochem 1986;47:665-667.

Scheinin H, MacDonald E, Scheinin M. Comparison of free MHPG in rat cerebrospinal fluid with free and conjugated MHPG in brain tissue: Effects of drugs modifying noradrenergic transmission. Eur J Pharmacol 1986;129:113-121.

Scheinin H, Virtanen R. Effects of yohimbine and idazoxan on monoamine metabolites in rat cerebrospinal fluid. Life Sci 1986;39:1439-1446.

Scheinin H, Virtanen R, Scheinin M. Alpha2-adrenoceptor agonists decrease free 3-methoxy-4-hydroxyphenylglycol in rat cerebrospinal fluid. Eur J Pharmacol 1986;123:115-121.

Hovi-Viander M, Kanto J, Scheinin H, Scheinin M. Tofisopam and midazolam: Differences in clinical effects and in changes of CSF monoamine metabolites. Brit J Clin Pharmaco 1985;20:492-496.

Scheinin H, Scheinin M. Repetitive measurement of monoamine metabolite levels in cerebrospinal fluid of conscious rats: Effects of reserpine and haloperidol. Eur J Pharmacol 1985;113:345-351.

Hyyppä MT, Scheinin H, Alaranta H, Hurme M, Lahtela K, Scheinin M. Neurotransmission and the experience of low back pain: No associations between CSF monoamine metabolites and pain emotions. Pain 1985;21:57-65.

Reviews in peer-reviewed scientific journals

Scheinin H, Alkire EC, Scheinin A, Alkire MT, Kantonen O, Långsjö J. Using positron emission tomography in revealing the mystery of general anesthesia: Study design challenges and opportunities, Methods Enzymol 2018;603:279-303.

Långsjö JW, Revonsuo A, Scheinin H. Harnessing anesthesia and brain imaging for the study of human consciousness. Curr Pharm Des 2014;20:4211-4224.

Laitio T, Jalonen J, Kuusela T, Scheinin H. The role of heart rate variability in risk stratification for adverse postoperative cardiac events. Anesth Analg. 2007;105:1548-1560.

Penttilä J, Scheinin H, Syvälahti E. Measurement of anticholinergic effects of psychotropic drugs in humans. Pharmacopsychiatry 2005;38:187-193.

Penttilä J, Kuusela T, Scheinin H. Analysis of rapid heart rate variability in the assessment of anticholinergic drug effects in humans. Eur J Clin Pharmacol 2005;61:559-565.

Hagelberg N, Jääskeläinen SK, Martikainen IK, Mansikka H, Forssell H, Scheinin H, Hietala J, Pertovaara A. Striatal dopamine D2 receptors in modulation of pain in humans: a review. Eur J Pharmacol 2004;500:187-192.

Sipilä J, Scheinin H, Grénman R. Pahanlaatuisten keuhkokasvainten palliatiivinen laserhoito. Duodecim 113, 51-55, 1997. (Laser bronchoscopy in palliative treatment of malignant obstructing endobronchial tumors)

Scheinin H, Kallio A, Koulu M, Scheinin M. Pharmacological effects of medetomidine in humans. Acta Vet Scand 1989;85 (Suppl.):145-147.

Scheinin H, Virtanen R, MacDonald E, Lammintausta R, Scheinin M. Medetomidine - a novel alpha2-adrenoceptor agonist, a review of its pharmacodynamic effects. Prog Neuro-Psychopharmacol Biol Psychiat 1989;13:635-652.

Reviews in peer-reviewed scientific journals (in Finnish)

Yli-Hankala A, Scheinin H. Voiko anestesian syvyyttä mitata aivosähkökäyrällä? Duodecim 2015;131:1929-1936.

Maksimow A, Jääskeläinen S, Scheinin H. Miten anestesia vaikuttaa aivoihin? Duodecim 2008;124:511-519. (How do anesthetics affect the brain?)

Penttilä J, Scheinin H, Syvälahti E. Antikolinergisen lääkevaikutuksen merkitys ja mittaaminen. Suomen Lääkärilehti 2005;60:2325-2328. (Significance and measurement of anticholinergic drug effect)

Scheinin H. Lääkkeen pitoisuuden ja vaikutuksen korrelaatio. Duodecim 1999;115:2275-2283. (Concentration-effect relationship)

Gordin A, Scheinin H. Kliinisen lääketutkimuksen ensimmäisen vaiheen haasteet ja huolet. Duodecim 1992. (The challenges of Phase I clinical trials)

Scheinin H, Idänpään-Heikkilä J. Kliininen lääketutkija: GCTP tulee - oletko valmis? Suomen Lääkärilehti 1990;45:2630-2635. (Clinical investigator and the Good Clinical Trial Practice)

Textbooks and chapters in textbooks (in Finnish)

Aantaa R, Scheinin H. Inhalaatioanestesia ja laskimoanestesia. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Lindgren L, Olkkola K, Ruokonen E). Kustannus Oy Duodecim, Helsinki, ss. 349-359, 2014. (Inhalational and intravenous anesthesia, in Finnish Textbook of "Anesthesiology and Intensive Care")

Scheinin H, Valtonen M. Laskimoanestesia-aineet ja sedaatiolääkkeet. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Lindgren L, Olkkola K, Ruokonen E). Kustannus Oy Duodecim, Helsinki, ss. 100-113, 2014. (Intravenous anesthetics and sedatives, in Finnish Textbook of "Anesthesiology and Intensive Care")

Scheinin H, Uusaro A. Anestesiologian ja tehohoidon kliinisen tutkimuksen perusteita. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Lindgren L, Olkkola K, Ruokonen E). Kustannus Oy Duodecim, Helsinki, ss. 43-53, 2014. (Fundamentals of clinical research in anesthesiology and intensive care medicine, in Finnish Textbook of "Anesthesiology and Intensive Care")

Olkkola KT, Scheinin H. Yleisnestesia-aineet. Kirjassa "Farmakologia ja toksikologia" (Toim. Koulu M, Mervaala E, Tuomisto J). Kustannusosakeyhtiö Medicina, Kuopio, ss. 345-358, 2012. (General anesthetics, in Finnish Textbook of "Pharmacology and Toxicology")

Huupponen R, Scheinin H, Tuominen J. Kliinisen lääketutkimuksen suorittaminen ja raportointi. Kirjassa "Kliininen farmakologia ja lääkehoito" (Toim. Neuvonen PJ, Backman JT, Himberg J-J, Huupponen R, Keränen T, Kivistö KT). Kandidaattikustannus Oy, Helsinki, ss. 987-1001, 2011. (Execution and reporting of clinical drug trials, in Finnish Textbook of "Clinical Pharmacology and Therapeutics")

Rosenberg P, Scheinin H, Olkkola KT. Anestesia-aineet. Kirjassa "Kliininen farmakologia ja lääkehoito" (Toim. Neuvonen PJ, Backman JT, Himberg J-J, Huupponen R, Keränen T, Kivistö KT). Kandidaattikustannus Oy, Helsinki, ss. 795-814, 2011. (Anesthetic drugs, in Finnish Textbook of "Clinical Pharmacology and Therapeutics")

Himberg J-J, Scheinin H. Lääkeaineen pitoisuuden ja vaikutuksen suhde. Kirjassa "Kliininen farmakologia ja lääkehoito" (Toim. Neuvonen PJ, Backman JT, Himberg J-J, Huupponen R, Keränen T, Kivistö KT). Kandidaattikustannus Oy, Helsinki, ss. 39-47, 2011. (Concentration-effect relationship, in Finnish Textbook of "Clinical Pharmacology and Therapeutics")

Aantaa R, Scheinin H, Valtonen M. Inhalaatioanestesia, laskimoanestesia ja yhdistelmäanestesia. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Lindgren L, Olkkola K, Takkunen O). Kustannus Oy Duodecim, Helsinki, ss. 378-389, 2006. (Inhalational, intravenous and combinational anesthesia, in Finnish Textbook of "Anesthesiology and Intensive Care")

Scheinin H, Valtonen M. Laskimoanestesia-aineet ja sedaatiolääkkeet. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Lindgren L, Olkkola K, Takkunen O). Kustannus Oy Duodecim, Helsinki, ss. 113-127, 2006. (Intravenous anesthetics and sedatives, in Finnish Textbook of "Anesthesiology and Intensive Care")

Scheinin H, Uusaro A. Anestesiologian ja tehohoidon kliinisen tutkimuksen perusteita. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Lindgren L, Olkkola K, Takkunen O). Kustannus Oy Duodecim, Helsinki, ss. 59-69, 2006. (Fundamentals of clinical research in anesthesiology and intensive care medicine, in Finnish Textbook of "Anesthesiology and Intensive Care")

Huupponen R, Scheinin H, Tuominen J. Kliinisen lääketutkimuksen suorittaminen. Kirjassa "Kliininen farmakologia" (Toim. Neuvonen PJ, Himberg J-J, Huupponen R, Kivistö KT, Ylitalo P). Kandidaattikustannus Oy, Helsinki, ss. 932-948, 2002. (Execution of a clinical drug trial, in Finnish Textbook of "Clinical Pharmacology")

Rosenberg P, Scheinin H, Olkkola K. Anestesia-aineet. Kirjassa "Kliininen farmakologia" (Toim. Neuvonen PJ, Himberg J-J, Huupponen R, Kivistö KT, Ylitalo P). Kandidaattikustannus Oy, Helsinki, ss. 748-770, 2002. (Anesthetic drugs, in Finnish Textbook of "Clinical Pharmacology")

Himberg J-J, Scheinin H. Lääkeaineen pitoisuuden ja vaikutuksen suhde. Kirjassa "Kliininen farmakologia" (Toim. Neuvonen PJ, Himberg J-J, Huupponen R, Kivistö KT, Ylitalo P). Kandidaattikustannus Oy, Helsinki, ss. 35-44, 2002. (Concentration-effect relationship, in Finnish Textbook of "Clinical Pharmacology")

Scheinin H. Lääketutkimuksen suunnittelu ja toteutus. Kirjassa "Kliinisen tutkijan opas" (Toim. Voipio-Pulkki L-M, Grenman R, Haapamäki M, Lenander-Lumikari M, Mäkinen J, Rautava P, Scheinin M, Vainikainen T). Kustannus Oy Duodecim, Helsinki, ss. 51-66, 2000. (Planning and execution of a clinical drug trial, in "Guide to Clinical Investigators")

Scheinin H, Valtonen M. Laskimoanestesia ja sedaatio. Kirjassa "Anestesiologia ja tehohoito" (Toim. Rosenberg P, Alahuhta S, Kanto J, Takala J). Kustannus Oy Duodecim, Helsinki, ss. 95-109, 1999. (Intravenous anesthesia and sedation, in Finnish Textbook of "Anesthesiology and Intensive Care")

Himberg J-J, Scheinin H, Aranko K. Kliinisten lääketutkimusten etiikka, normit, ohjeet ja valvonta. Kirjassa "Kliininen farmakologia" (Toim. Neuvonen P, Himberg J-J, Iisalo E, Mattila MJ, Ylitalo P). Kandidaattikustannus Oy, Helsinki, ss. 673-680, 1994. (Ethical and regulatory aspects of clinical drug studies, in Finnish Textbook of "Clinical Pharmacology")

Other publications

Scheinin H. Yleisanestesia tietoisuuden tutkimisen työkaluna. Kirjassa ”Mielen salat” (Toim. von Bonsdorff P, Ylikangas M). Suomen Akatemia, Helsinki, ss. 161-171, 2017.

Scheinin H. Yleisanestesian mysteeri – mitä aivoissa tapahtuu, kun ihminen nukutetaan ja herätetään? Tehohoito 2015;33:42-44.

Scheinin A, Långsjö J, Scheinin H. Voiko anestesiologia auttaa ihmisen tietoisuuden neuraalisten mekanismien selvittämisessä? Finnanest 2014;47:224-229.

Scheinin H. Yleisanestesian mysteeri. Turun Sanomat 29.8.2013.

Scheinin H, Långsjö JW. Why does bispectral index monitoring not perform better? Anesthesiology 2013;118:1233-1234. (Letter to the editor)

Scheinin H. Avidanin artikkelin tutkimusasetelma oli tarkoituksellinen. Finnanest 2012;45:209. (Letter to the editor)

Långsjö JW, Alkire MT, Kaskinoro K, Hayama H, Maksimow A, Kaisti KK, Aalto S, Aantaa R, Jääskeläinen SK, Revonsuo A, Scheinin H. Aivojen syvät rakenteet ovat kriittisiä ihmisen tajunnalle (J Neurosci, in press). Duodecim 2012;128:1037-1038. (Resume)

Tarvainen MP, Georgiadis S, Lipponen JA, Laitio T, Karjalainen PA, Scheinin H, Kaskinoro K. Analysis of heart rate variability dynamics during propofol and dexmedetomidine anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:1634-7.

Penttilä J, Scheinin H. Antikolinergista vaikutusta voi mitata. Suomen Lääkärilehti 65, 3588, 2010. (Letter to the editor)

Tarvainen MP, Georgiadis S, Lipponen JA, Laitio T, Kaskinoro K, Scheinin H, Karjalainen PA. Analysis of heart rate variability dynamics during propofol anesthesia. Proceedings of the World Congress 2009 for Medical Physics and Biomedical Engineering, Munich, Germany, September 2009.

Georgiadis SD, Tarvainen MP, Kaskinoro K, Maksimow A, Kärki T, Jääskeläinen S Scheinin H, Karjalainen PA. Kalman smoother based time-varying spectrum estimation of EEG during single agent propofol anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2009;1:5709-12.

Georgiadis SD, Tarvainen MP, Niskanen J-P, Kaskinoro K, Maksimow A, Jääskeläinen S, Scheinin H, PA Karjalainen. Time-varying multivariate correlation analysis of EEG during low dose propofol anesthesia. Proceedings of the World Congress 2009 for Medical Physics and Biomedical Engineering, Munich, Germany, September 2009.

Scheinin H. Anestesian mysteeri. Tieteessä tapahtuu 2/2007:15-18.

Abstracts of the X Turku PET Symposium, May 28-31, 2005, Turku, Finland (Eds. Nyman MJ, Oikonen V, Turiceanu M, Scheinin H). Annales Universitatis Turkuensis, Ser. D, No. 660, 124 pages, 2005.

Laitio T, Kuusela T, Huikuri H, Jalonen J, Kentala E, Makikallio T, Helenius H, Pullisaar O, Hartiala J, Scheinin H. Prediction of postoperative myocardial ischemia by fractal heart rate dynamics (in response). Anesth Analg. 2005;100:289-290. (Letter to the editor)

Scheinin H. Positron Emission Tomography (PET). Proceedings of SSAI 2003 Congress. Acta Anaesthesiol Scand 2003;47:76.

Scheinin H. Miksi ja missä uusia lääkkeitä kehitetään? Kirjassa "Lääkkeet & Terveys". Lääketietokeskus, Helsinki, 2002. (Why and where are new drugs developed?)

Scheinin H. Ksenon – Tulevaisuuden anesteetti? Finnanest 2002;35:223-226. (Xenon – Anesthetic of the future?)

Laitio T, Scheinin H, Kuusela T, Mäenpää M, Jalonen J. Mitä sydämen sykevaihtelu kertoo? Finnanest 2001;34:249-255. (What does heart rate variability tell us?)

Scheinin H. Lääketutkimuksen suunnittelu ja toteutus A.D. 2001. Finnanest 2001;34:241-248. (Planning and execution of a clinical drug trial a.d. 2001)

Scheinin H. Riittääkö otoskoko? Finnanest 2001;34:566-567. (Is the sample size adequate?)

Scheinin H. Anestesian arvoitus - antaako PET uusia näkökulmia? Finnanest 2000;33:177-178. (The mystery of anesthesia - Does PET open new viewpoints?)

Scheinin H, Scheinin M, Knuuti J. PET in drug discovery and development: an introduction. Ann Med 1999;31:430-431.

Ahokoski O, Virtanen A, Huupponen R, Scheinin H, Salminen E, Kairisto V, Irjala K. Mihin tahtiin hyrräävät miehen hormonit? Duodecim 1999;115:2114-2115.

Laitio T, Kentala E, Jalonen J, Huikuri H, Scheinin H. Kaaosteoria, fraktaaliset korrelaatio-ominaisuudet ja sydämen ohitusleikkaus. Finnanest 1998;31:203-205. (Chaos theory, fractal correlation properties and coronary artery bypass surgery)

Scheinin H. Miksi ja missä uusia lääkkeitä kehitetään? Kirjassa "Lääkkeet & Terveys". Lääketietokeskus, Helsinki, 1998. (Why and where are new drugs developed?)

Scheinin H. Kliinisen tutkimuksen karikoita II - satunnaistaminen ja sokkoutus. Finnanest 1998;31:215-217. (Pitfalls in clinical trials - randomization and blinding)

Scheinin H. Kliinisen tutkimuksen karikoita - riittääkö potilasmäärä? Finnanest 1997;30:245-250. (Pitfalls in clinical trials - The sample size)

Scheinin H. Opiaatteja vaikean kroonisen kivun hoitoon. Tabu 1997 (3):6-8. (New opiates for the treatment of severe chronic pain)

Scheinin H. Tutkimus turvaa terveen kehityksen. Kirjassa "Lääkkeet & Terveys". Lääketietokeskus, Helsinki, ss 30-34; 36-40, 1996. (Research secures sound development)

Scheinin H. Shortcomings in clinical documentation. In Preclinical and Clinical Evaluation of Medicinal Products, Proceedings of the NLN Regulatory Seminars 1996, April 24-25, 1996, Malmö, Sweden. NLN Publication No 41, Stockholm, pp 31-36, 1996.

Scheinin H. Uudet nopeat inhalaatioanesteetit desfluraani ja sevofluraani. Tabu 1996 (3):13-16. (The new fast volatile anesthetics desflurane and sevoflurane)

Scheinin H. Uuden lääkkeen kliiniseen dokumentointiin liittyvät kansainväliset vaatimukset ja normit - määräysten viidakko. Tabu 1996 (1):11-13. (International standards and requirements governing clinical drug development)

Tieteellinen tutkimus anestesiologian yksikössä uusien haasteiden edessä. Tietyks 1996.

Lund V, Kentala E, Scheinin H, Klossner J, Sariola-Heinonen K, Jalonen J. Hyperbaric oxygen therapy and heart rate variability in healthy volunteers. Proceedings of the International Joint Meeting on Hyberbaric and Underwater Medicine (September 4-8, 1996, Milan, Italy), pp 121-123, 1996.

Scheinin H. Tilastollinen vai kliininen ero? Duodecim 111, 1966-1967, 1995. (Letter to the editor)

Scheinin H. Terapiresistent depression. Farmaka i Fokus no 1, 1995. (Therapy resistant depression)

Scheinin H. Kokain och marijuana missbruk allt vanligare orsak till "rattfylleri" i USA, Drogtester, 1995. (Resume)

Scheinin H. Uudet non-depolarisoivat lihasrelaksantit mivakuuri ja rokuroni. Tabu 1995 (3):24-26. (The new non-depolarizing muscle relaxants mivacurium and rocuronium)

Ali-Melkkilä T, Scheinin H. Serotoniini3-reseptorin salpaajat postoperatiivisen pahoinvoinnin hoidossa. Finnanest 1994;19:161-165. (5HT-3-antagonists in the treatment of postoperative nausea and vomiting)

Scheinin H. Quo vadis kliininen tutkimus? Suomen Lääkärilehti 48, 3648-3649, 1993. (Letter to the editor)

Scheinin H, Leino R. Vinkistä vihiäkö? Duodecim 109, 1097, 1993. (Letter to the editor)

Scheinin H. Deksmedetomidiini - mitä uutta? Finnanest 1993;19:151-158. (Dexmedetomidine - an update)

Scheinin H. Reporting of clinical trials in the clinic. In Quality Assurance in Clinical Drug Research, Proceedings of Nordic Symposium on Good Clinical Trial Practice, October 7-8, 1992, Oslo, Norway. NLN Publication No 33, Stockholm, pp 77-80, 1993.

Scheinin H. Good Clinical Trial Practice (pääkirjoitus/Editorial): Lääkeuutiset 1991 (1):5.

GCTP-erikoisnumero (Toim. Scheinin H). Lääkeuutiset 1/1991, 1991. (Special Issue on Good Clinical Trial Practice)

Scheinin H. Good Clinical Trial Practice lääketehtaan kannalta. Lääkeuutiset 1991 (1):9-12. (Pharmaceutical industry and the Good Clinical Trial Practice)

Scheinin H. Toremifeenin kansainvälinen tutkimusohjelma ja tulosten yhteenveto. Lääkeuutiset 1989 (4):231-234. (The international study program of toremifene and summary of results)

Kangas L, Käpylä H, Scheinin H. Toremifeeni - ideasta potilaskäyttöön (pääkirjoitus). Lääkeuutiset 1989 (4):153. (Toremifene - from idea to clinical practice, Editorial)

Toremifeeni-erikoisnumero (Toim. Kangas L, Käpylä H, Scheinin H). Lääkeuutiset 4/1989, 1989. (Special Issue on Toremifene)

Scheinin H. Suomalaisen lääketeollisuuden tulevaisuuden haasteet - Analyysi lääkealan ympäristömuutoksista ja kansainvälistymisen edellytyksistä. JOKO-tutkielma 1989. (Future challenges of the Finnish pharmaceutical industry - Analysis of business environment and internationalizing prospects)

Hyyppä MT, Scheinin M, Scheinin H, Alaranta H, Hurme M, Lahtela K. Do the referees of pain read pain? Pain 33, 131, 1988. (Letter to the editor)

Scheinin H. Kipulääkkeiden vaikutusmekanismeista. Eläinlääkeuutiset 1987 (1):8-11. (On the mechanisms of action of analgesics)

Reunanen M, Heinonen E, Lehto H, Scheinin H, Anttila M, Kahela P. Harhauttava slow? Suomen Lääkärilehti 41, 2866-2867, 1986. (Letter to the editor)

Proceedings of the IV Meeting of Finnish Neurochemists, Turku, 5th and 6th of June, 1986 (Eds. Åkerman K, Molnar G, Scheinin H, Scheinin M). Publications of the Research Institute of the Åbo Akademi Foundation, Åbo Akademi, Turku, Finland.

Scheinin H. Monitoring of drug-induced changes in monoamine metabolites in rat cerebrospinal fluid. Thesis. Turku 1986.

Syvälahti E, Lindberg R, Scheinin M, Hietala J, Pihlajamäki K, Scheinin H. On the pharmacokinetic and pharmacodynamic profile of the novel antidepressive, nomifensine. Proceedings of 4th Congress of the Hungarian Pharmacological Society with International Participation, Vol 2, pp 407-411, 1985.

Scheinin H, Hyyppä MT, Scheinin M, Alaranta H, Hurme M, Lahtela K. Monoamine metabolites in cerebrospinal fluid of patients with low back pain. Acta Universitatis Tamperensis ser B, vol 21, 116-122, 1984.

Abstracts

145 Abstracts.

Patents and patent applications

Scheinin H, Alkire M, Kaskinoro K, Långsjö J. Method for changing an individual's state of consciousness. US Patent Application 20120083647, 5 April 2012.

Laitio T, Scheinin H, Huikuri H, Viertio-Oja H, Merilainen P. Method and Arrangement for Obtaining Diagnostic Information of a Patient. US 20080167565, 10 July 2008.

Laitio T, Huikuri H, Jalonen J, Kentala E, Scheinin H. Method and arrangement for predicting perioperative myocardial ischemia.US 7231244, 12 June 2007.

Särkelä M, Viertiö-Oja HE, Jääskeläinen S, Långsjö J, Maksimow A, Salmi E, Scheinin H. Monitoring of the cerebral state of a subject. EP 1741388, US 20070010755, 10 January 2007.

Sinclair D, Lammintausta R, Scheinin H. Method for treating alcoholism with nalmefene. US5086058, EP0531415, WO/1991/018605, 12 December 1991.

 

Updated July 2018